ColoPan
Exploring how tumours respond to different treatments to support personalised cancer care
The ColoPan study aims to improve personalised treatment approaches for pancreatic ductal adenocarcinoma and colorectal cancer. Due to their complex biology, genetic diversity and resistance mechanisms, these cancers can respond very differently to treatment, making it difficult to predict which therapies will be most effective for each individual. Building on an innovative approach known as Personalised Functional Profiling (PFP), researchers will combine detailed molecular analyses of patients’ tumours with drug testing on patient-derived tumour models (organoids) to better understand how tumours from different patients respond to available treatments. Although the results of this study will not be used to guide participants’ treatment decisions, they will help evaluate new approaches that could support more personalised cancer care in the future.
The ColoPan study is closely associated with the SOCS project – Luxembourg’s project dedicated specifically to colorectal cancer – and will benefit from colorectal cancer samples collected under this national colorectal cancer reference programme.
About the study
Locations
9, rue Edward Steichen
L-2540 Luxembourg
L-1130 Luxembourg
Contact
Who can participate?
Eligible participants
The study is recruiting:
- Are 18 years of age or older.
- Willing and able to comply with the protocol for the duration of the study, including data and sample collection.
- Are scheduled for surgery or biopsy (primary tumour or metastasis) PDAC.
- Are willing and able to provide written informed consent.
Exclusion criteria
- Are pregnant, planning a pregnancy or breastfeeding
- Have known active Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), or Hepatitis C Virus (HCV) infection.
- Have any other life-threatening illness, significant organ dysfunction or any clinically relevant conditions that, according to the hospital physician, could compromise safety
What will participants do?
01.
Sign an informed consent form
This must be completed before any study procedures take place.
02.
Provide a blood sample
This will be collected during the inclusion visit.
03.
Allow the collection of tissue samples
Researchers may collect tissue samples during a biopsy or collect residual tissue samples during a routine surgery.
04.
Provide clinical information
This will include information related to your diagnosis, treatment, and follow-up.
05.
Attend biannual follow-up visits
These will take place for up to 5 years, during which your clinical information will be updated.
Contact & location
Hôpitaux Robert Schuman (HRS) – Site Kirchberg
Hôpitaux Robert Schuman (HRS) – Site Kirchberg
9, rue Edward Steichen
L-2540 Luxembourg
Hôpitaux Robert Schuman (HRS) – ZithaKlinik
44 Rue d’Anvers,
L-1130 Luxembourg
Study team
Participating institutions
Funded by
Hôpitaux Robert Schuman (HRS)
Luxembourg Institute of Health (LIH)
University of Luxembourg (UL)
Fondation Hôpitaux Robert Schuman
Partly funded by Programme de Recherche Clinique (PRC) hospitalière
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