Markers4Care
Finding new ways to monitor and improve treatments for peanut and tree nut allergies
Food allergies can have a significant impact on daily life and may increase the risk of severe allergic reactions. Oral immunotherapy (OIT) is an emerging treatment that aims to increase tolerance to specific foods by gradually introducing small, increasing amounts of the allergen over time. This approach may help improve safety and quality of life for people living with food allergies. However, there is still the need to develop reliable biomarkers that could help predict how well a person responds to treatment. The goal of this research project is to better understand how the immune system changes during oral immunotherapy so as to identify immune markers in blood samples to measure, monitor and predict the progression and efficacy of oral immunotherapy, ultimately supporting more personalised approaches to allergy care.

About the study
Locations
4, rue Ernest Barblé
L-1210 Luxembourg
Contact
Want to learn more?
Contact & location

Centre Hospitalier de Luxembourg – CHL KannerKlinik
CHL KannerKlinik
4, rue Ernest Barblé
L-1210 Luxembourg
Who could participate?
Eligible participants
The study recruited nut allergic children from 2 years of age with an initial oral food challenge (OFC) allowing the start of oral immunotherapy (OIT) at home during 18 months.

What did participants do?
Participants completed the following procedures:
01.
Blood samples
during oral food challenge (at baseline, during and at the final oral food challenge), 2 times during oral immunotherapy (6 and 12 month).
02.
Stool sampling
at baseline and at the end of the study.
03.
Daily introduction of a nut at home.
Only in the oral Immunotherapy group.
Principal Investigator

Dr Annette Kuehn
Group Leader, Molecular & Translational Allergology
Luxembourg Institute of Health (LIH)
Funded by
The Luxembourg National Research Fund (FNR)
The Ministry of Higher Education and Research (MESR).
Want to learn more about the study?
Visit the website for full study details, scientific publications and research background.
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