TSI 2.0
Collection of samples from leukemia and lymphoma patients compared to healthy controls to study tumor cells and their microenvironment
TSI 2.0 aims to improve our understanding of chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL) by studying how cancer cells interact with their surrounding environment and why some patients develop resistance to treatment. By collecting samples from patients and healthy volunteers, researchers seek to identify new biomarkers that could improve diagnosis, predict treatment response, and support more personalised care. The study also investigates how cancer cells communicate with other cells in the body, paving the way for the development of innovative diagnostic tools and more effective therapies.
About the study
Locations
L-1210 Luxembourg
L-1210 Luxembourg
L-4602 Niederkorn
Luxembourg
L-4123 Esch-sur-Alzette
Luxembourg
L-4059 Esch-sur-Alzette
Luxembourg
Contact
Want to learn more?
Who can participate?
Eligible participants
The study is recruiting:
A patients:
- Are 18 years of age or older.
- Have been diagnosed with chronic lymphocytic leukemia (CLL) or another B-cell malignancies where resection or biopsy of lymph node is needed (e.g. DLBCL, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, Burkitt lymphoma).
- Are willing and able to take part in the study and provide written informed consent.
A healthy volunteer:
- Are 18 years of age or older.
- Are in good general health.
- Are willing and able to take part in the study and provide written informed consent.
Exclusion criteria
You may not be eligible to participate if you:
- Are unwilling or unable to provide written informed consent
A healthy volunteer
- Have an acute illness, such as a viral infection, or chronic medical condition, such as diabetes or cancer.
What will participants do?
01.
Complete pre-screening
During a routine visit, you will discuss the study with your treating physician to confirm whether you are eligible to participate.
02.
Read and sign an informed consent form
This must be completed before any study-specific procedures take place. The study team will explain the study and answer any questions you may have.
03.
Provide a blood sample
This will be collected during your routine hospital visit or, if applicable, during a home visit arranged by the study team.
04.
Attend follow-up visits
These will take place approximately every 6 months. Additional blood samples may be collected as part of your routine care and study follow-up.
Contact & location
Centre Hospitalier de Luxembourg – CHL Centre
4 rue Barblé
L-1210 Luxembourg
Luxembourg Research Clinic (LRC)
6, Rue Nicolas-Ernest Barblé,
L-1210 Luxembourg
Medical practice Dr Stefan Rauh
187, avenue de la Liberté,
L-4602 Niederkorn
Luxembourg
Medical practice Dr Serge Meyer
55 Rue du Fossé,
L-4123 Esch-sur-Alzette
Luxembourg
Medical practice Dr Françoise Le Moine
2 Rue du Cimetière,
L-4059 Esch-sur-Alzette
Luxembourg
Study team
Dr Stefan Rauh
MD, Specialist in Internal Medicine and Oncology
Centre Hospitalier Emile Mayrisch (CHEM)
Dr Serge Meyer
MD
Participating institutions
Funded by
Luxembourg Institute of Health (LIH)
Want to learn more about the TSI Group?
Visit the Luxembourg Institute of Health for more information about the TSI Group and their scientific publications and research background.
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