PRECISION-PDX 2.0
Personalised medicine for central nervous system tumour patients: from basic research to preclinical models
The PRECISION-PDX study aims to improve the understanding and treatment of tumours of the central nervous system, including brain and spinal cord tumours. By collecting tumour tissue donated by patients, researchers are building a national biobank that will support research into the biological mechanisms of these cancers and help identify new biomarkers for diagnosis and treatment. The donated tissue is also used to develop patient-derived tumour models – laboratory models that closely resemble each patient’s tumour. These models allow researchers to study how tumours behave and to test potential treatments before they are used in patients, helping to accelerate the development of more effective and personalised therapies for people living with brain and spinal cord tumours.
About the study
Locations
L-1210 Luxembourg
Contact
Want to know more?
Who can participate?
Eligible participants
The study is recruiting:
- All patients, female or male, with a tumor (benign or malignant) in the central nervous system who are undergoing surgical resection or biopsy as part of routine clinical care.
- Are willing and able to provide written informed consent (or, for children, have consent provided by a parent or legal guardian).
- People of all ages may be eligible to participate.
Exclusion criteria
Have a known active prion disease or certain active viral infections,
such as HIV, hepatitis A, B or C, or cytomegalovirus (CMV).
What will participants do?
01.
Discuss the study with the healthcare team
This will take place before the scheduled surgery. The patients will receive detailed information about the study and have the opportunity to ask questions before deciding whether to participate.
02.
Sign an informed consent form
This must be completed before your any study procedure (blood sampling, surgery, etc.). The patients are free to withdraw their consent at any time without affecting their medical care.
03.
Provide a blood sample
This will be collected before the surgical procedure.
04.
Allow the use of remaining tumour tissue
Researchers may use a small portion of the tumour tissue removed during the patient’s routine surgery that is not needed for diagnosis or treatment. No additional surgical procedure will be performed for the study.
05.
Allow the collection of medical information
Researchers may collect information from the patient’s medical records, including information about their diagnosis, treatment, and long-term follow-up. If the tumour recurs or spreads within the central nervous system, available clinical information and tumour samples collected during patient’s routine care may also be included in the study.
Contact & location
Centre Hospitalier de Luxembourg – CHL Centre
4 rue Barblé
L-1210 Luxembourg
Principal Investigator
Principal investigator
Dr Anna Golebiewska, Phd
Group Leader, NORLUX Neuro-Oncology Laboratory
Principal investigator
Dr Guy Berchem, MD, PhD
Oncologist, Medical Director
Principal investigator
Prof Dr Frank Hertel, MD, PhD
Neurosurgeon
Study team
Participating institutions
Funded by
The Luxembourg Institute of Health (LIH)
Want to learn more about the study?
Visit the NORLUX Neuro-Oncology Laboratory website for full study details, scientific publications and research background.
Related news & updates
Luxembourg Research Clinic was launched during the Clinical Research Conference to strengthen patient access to clinical research
On September 29, the Luxembourg Institute of Health (LIH) and its national partners officially inaugurated the Luxembourg Research Clinic (Fuerschungsklinik…
Small country, significant capacity
Luxembourg may be one of Europe’s smallest countries, but the Luxembourg Research Clinic demonstrates how its highly connected national network…
Joint action on personalised cancer medicine kicks off
Luxembourg's Research Clinic has been admitted as a full member of ECRIN, the European Clinical Research Infrastructure Network, opening access…
Related events
Clinical Research Luxembourg Conference
Why does clinical research matter today in Luxembourg? Clinical research plays a vital role in improving patient care, driving medical…